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Ensuring Statistical Power in Step-Wedge Designs with Unequal Cluster Sizes
Jan 22, 2018 - 12:00pm to 1:00pm
700-828 W. 10 Ave., VGH Research Pavilion
Phase II of the TEC4Home project is a randomized trial of the effectiveness of Home Health Monitoring in patients with COPD. Patients will be recruited from 22 hospitals across BC with hospitals randomized using a step-wedge design. If the randomization is unconstrained, large variability across hospitals in the number of patients enrolled increases the risk that the trial will be underpowered. I will discuss the heuristics underlying this problem and potential solutions.
- Complex study designs involve complex power calculations.
- The risk that the realized power (achieved in the actual study) will be lower than the (pre-study) target power should be considered when designing a randomization plan.
C2E2 Rounds are presented Mondays from 12:00 pm to 1:00 pm in room 700 of the VGH Research Pavilion, 828 West 10th Avenue, Vancouver, BC.
Feb 25, 2019 // Noah Silverberg
Mar 4, 2019 // Donald Griesdale